HSP Types

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Hereditary spastic paraplegia (HSP) is the name for a group of inherited diseases, which have lower limb weakness at their core. New types of HSP are being regularly discovered, thanks to advances in genetics.

HSP types are identified by the letters SPG then a number. The numbers correlate to the discovery of the faulty gene, so SPG1 was the first to be discovered, in 1994, with SPG79 being the most recent. This table contains the types of HSP discovered up to 2016.

It is possible to have a HSP diagnosis, without knowing your HSP type.

HSP type

Gene name

Age of onset

Pure / complicated

SPG1

L1CAM

Early

Complicated

SPG2

PLP1

Variable

Variable

SPG3A

ATL1

Early

Pure

SPG4

SPAST

Variable

Pure

SPG5A

CYP7B1

Variable

Variable

SPG6

NIPA1

Variable

Pure

SPG7

SPG7

Variable

Variable

SPG8

KIAA0196

Adult

Pure

SPG9A

ALDH18A1

Teenage

Complicated

SPG9B

ALDH18A1

Early

Complicated

SPG10

KIF5A

Early

Variable

SPG11

SPG11

Variable

Complicated

SPG12

RTN2

Early

Pure

SPG13

HSP60

Variable

Pure

SPG14

Adult

Complicated

SPG15

ZFYVE26

Early

Complicated

SPG16

Early

Complicated

SPG17

BSCL2

Teenage

Complicated

SPG18

ERLIN2

Early

SPG19

Adult onset

Pure

SPG20

SPG20

Early onset

Complicated

SPG21

ACP33

Early onset

Complicated

SPG22 

SLC16A2

Early onset

Complicated

SPG23

RIPK5

Early onset

Complicated

SPG24

Early onset

Pure

SPG25

Adult

Complicated

SPG26

B4GALNT1

Early onset

Complicated

SPG27

Variable

Pure

SPG28

DDHD1

Early onset

Variable

SPG29

Teenage

Complicated

SPG30

KIF1A

Teenage

Complicated

SPG31

REEP1

Early onset

Pure

SPG32

Childhood

Complicated

SPG33

ZFYVE27

Adult

Pure

SPG34

Teenage/Adult

Pure

SPG35

FA2H

Childhood

Complicated

SPG36

Teenage/Adult

Complicated

SPG37

Variable

Pure

SPG38

Teenage/Adult

Complicated

SPG39

PNPLA6

Childhood

Complicated

SPG41

Adolescence

SPG42

SLC33A1

Variable

Pure

SPG43

C19orf12

Childhood

Variable

SPG44

GJC2

Childhood/teenage

Complicated

SPG45

NT5C2

Infancy

Complicated

SPG46

GBA2

Variable

Complicated

SPG47

AP4B1

Childhood

Complicated

SPG48

AP5Z1

6th decade

Complicated

SPG49

TECPR2

Infancy

Complicated

SPG50

AP4M1

Infancy

Complicated

SPG51

AP4E1

Infancy

Complicated

SPG52

AP4S1

Infancy

Complicated

SPG53

VPS37A

Childhood

Complicated

SPG54

DDHD2

Childhood

Complicated

SPG55

C12orf65

Childhood

Complicated

SPG56

CYP2U1

Childhood

Variable

SPG57

TFG

Early

Complicated

SPG58

KIF1C

Within first two decades

Complicated

SPG59

USP8

Childhood

Pure

SPG60

WDR48

Infancy

Complicated

SPG61

ARL6IP1

Infancy

Complicated

SPG62

ERLIN1

Childhood

Complicated

SPG63

AMPD2

Infancy

Variable

SPG64

ENTPD1

Childhood

Complicated

SPG66

ARSI

Infancy

Complicated

SPG67

PGAP1

Infancy

Complicated

SPG68

KLC2

Childhood

Complicated

SPG69

RAB3GAP2

Infancy

Complicated

SPG70

MARS

Infancy

Variable

SPG71

ZFR

Childhood

Complicated

SPG72

REEP2

Infancy

Pure

SPG73

CPT1C

Adult

SPG74

IBA57

Childhood

SPG75

MAG

Childhood

SPG76

CAPN1

Adult

SPG77

FARS2

Childhood

SPG78

ATP13A2

Adult

SPG79

UCHL1

Childhood 

Yet to Be Confirmed/Classified

HSP type

Gene name

Age of onset

Pure / complicated

HSNSP

CCT5

Early

SERAC1

Early

KY

Early

PLA2G6

Early

ATAD3A

Early

KCNA2

Early

Granulin

POLR3A